vaccines have markers in our blood that indicate a more active immune response, but a new mouse study has hinted at a simple way to reduce this reaction, while still maintaining the vaccine's vital impact.Researchers from the Duke-NUS Medical School in Singapore analyzed blood samples from 175 healthcare workers who received the Pfizer vaccine. They found those who experienced fatigue expressed more genes related to the activity of T and natural killer immune cells.
"This study provides a first insight into the molecular basis of a side effect that many have experienced following mRNA vaccination,"Most vaccines are administered into the muscle layer of our tissues. This is because many immune cells that learn to recognize foreign invaders reside here and muscle tissue has an excellent blood supply for easy transport elsewhere in the body.
The immune cells here can quickly take up the antigens in the vaccine and deliver them to the nearest lymph nodes; in the case of the inoculation site on your shoulder, the nearest lymph nodes are in your armpit. In contrast, the fat layer beneath your skin has far less blood supply and immune cells, meaning your immune cells will not encounter the antigens released here or get them to the lymph nodes as fast.This provides time for other molecules in the surrounding area to react to the antigens, possibly degrading them so that they no longer accurately represent the threat they're supposed to be teaching our immune system to be wary of.
Sounds like this may also make a difference in how body fat comes into play with a vaccination. I wonder if it is different in a lean as opposed to more chubby patient. Us chubby folks have a larger fatty layer. eeven at vaccination sites.
yeah...it has nothing to do with gender or sex
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