Particles of SARS-CoV-2 bud from a cell. The virus and related pathogens are inhibited by an antibody culled from a person who had COVID-19. Credit: Steve Gschmeissner/Science Photo Library
A newly isolated antibody that blocks SARS-CoV-2 from infecting cells could one day be used to treat infections caused by current and future variants of the virus that causes COVID-19, and even infections from related virusesDavid Veesler and his colleagues at the University of Washington, Seattle, searched the blood of an infected person for antibodies that bind the SARS-CoV-2 spike protein, which lets the virus enter human cells.
S2K146 also binds spike protein from the two related viruses: SARS-CoV, which caused an outbreak of respiratory disease in 2002–2003, and WIV-1, which infects bats and has the potential to infect humans. Administering S2K146 to hamsters infected with SARS-CoV-2 greatly reduced or eliminated viral replication.
The team found that mutations that prevented S2K146 from binding to spike protein also rendered SARS-CoV-2 much less effective at infecting cells. This suggests that the virus is unlikely to mutate its way out of S2K146’s grasp.
Trump supporters are the worst antibodies.
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