are comparably efficacious, on average,” said Hollon. “Neither is a panacea,” he cautioned, “since not everybody responds to either one.” But those who don’t get better with one treatment may benefit from the other.. “Aim to do whatever you would do if you weren’t depressed,” advised Hollon, though he is quick to add that the behavioral part of CBT is not simply advice to “get moving.
The limitations of depression medication are no fault of the medications themselves. “The antidepressant medications are goodmedications,” said Hollon, “You don’t get tolerance and withdrawal in the classic sense, and they’re relatively safe and efficacious. But it’s like aspirin—you take an aspirin today to get rid of a headache, but it doesn’t mean it’s going to keep you from getting a headache next week unless you keep taking aspirin on a continuous basis.
“The evidence is pretty clear,” said Hollon. “There’s not a deficit—there’s an excess.” He described findings from athat measured metabolite levels from blood in the brain, which indicate how much serotonin the brain is using. Results from this study revealed that serotonin levels were elevated among those with clinical depression, and returned to normal levels following medication treatment. Other studies (e.g.
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