Using antibodies to detect Alzheimer’s disease

Interview conducted by Emily Henderson, B.Sc.Jun 8 2020 Thought LeadersProfessor Michele VendruscoloProfessor of BiophysicsUniversity of Cambridge News-Medical speaks to Professor Michele Vendruscolo about his research that uses antibodies to detect Alzheimer's disease, which could help to improve drug discovery.

What are amyloid-beta oligomers? Among the proteins that aggregate in Alzheimer’s disease, a very special place is occupied by a particular protein fragment known as amyloid-beta. A central role in the amyloid hypothesis is played by amyloid-beta oligomers, which are highly elusive particles that are extremely difficult to observe. Without knowing for certain the positions and numbers of the oligomers it has been highly challenging to prove or disprove the amyloid hypothesis.Download a copy today

What is the antibody you have designed and how did you design it? The antibody that we have designed is capable of binding specifically to amyloid-beta oligomers, thus opening the possibility of detecting their presence and of quantifying their numbers. How could this tool be used to discover more drugs for Alzheimer’s treatment and improve clinical trials? There are at least three major ways.

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