Stroke genetics informs drug discovery and risk prediction across ancestries - Nature

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New research links dozens more genes with stroke, identifies potential drug targets nature

. We thank the participants and staff of contributing studies. We also thank Michèle M. Sale, who passed away in 2018, for her important contributions to some of the studies included in this manuscript, as principal investigator of one of the grants that funded “The Sea Islands Genetics Network ” . She contributed specifically to SIGNET-REGARDS from the REasons for Geographic And Racial Differences in Stroke and served as a key contributor to SiGN, COMPASS and METASTROKE.

Marios K. Georgakis, Livia Parodi, Jonathan Rosand, Christopher D. Anderson, Ernst Mayerhofer & Christopher D. Anderson Kuang Lin, Zhengming Chen, Cornelia M. van Duijn, Robert Clarke, Rory Collins, Richard Peto, Yiping Chen, Zammy Fairhurst-Hunter, Michael Hill, Alfred Pozarickij, Dan Schmidt, Becky Stevens, Iain Turnbull, Iona Y. Millwood, Keum Ji Jung & Robin G. Walters

Bendik Slagsvold Winsvold, Sigrid Børte, Kristian Hveem, Ben M. Brumpton, Jonas B. Nielsen, Maiken E. Gabrielsen, Anne H. Skogholt, Ben M. Brumpton, Maiken E. Gabrielsen, Amy E. Martinsen, Jonas B. Nielsen, Kristian Hveem, Laurent F. Thomas & John-Anker ZwartBendik Slagsvold Winsvold & Anne H. Aamodt

Center for Genomic and Precision Medicine, College of Medicine, University of Ibadan, Ibadan, NigeriaNeuroscience and Ageing Research Unit Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, NigeriaDepartment of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands

British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UKDepartment of Genetics, Novo Nordisk Research Centre Oxford, Oxford, UKDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USADepartment of Surgery, University of Pennsylvania, Philadelphia, PA, USADepartment of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka,...

Mirjam I. Geerlings, N. Charlotte Onland-Moret, Paul I. W. de Bakker, Mirjam I. Geerlings, Jet M. J. Vonk, N. Charlotte Onland-Moret, Ina L. Rissanen & Thomas LimanVilmundur Gudnason, Vilmundur Gudnason & Sigurdur SigurdssonVilmundur Gudnason, Kari Stefansson & Vilmundur Gudnason Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA

 

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Nature Any of these genes influenced by a certain gene therapy

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