Effects of Vaccination and Previous Infection on Omicron Infections in Children | NEJM

, available with the full text of this letter at NEJM.org. Among 887,193 children 5 to 11 years of age in the study, 193,346 SARS-CoV-2 infections occurred between March 11, 2020, and June 3, 2022; a total of 309 of the infected children were known to be hospitalized, and 7 were known to have died . A total of 273,157 children had received at least one dose of the BNT162b2 vaccine between November 1, 2021, and June 3, 2022.

The estimated effectiveness of the BNT162b2 vaccine against SARS-CoV-2 infection is shown as a function of time since the first dose, according to the date of the first dose and according to previous infection status . The estimated effectiveness of previous SARS-CoV-2 infection against reinfection is shown as a function of time since previous infection, according to the variant type, among unvaccinated children and among vaccinated children .

The immunity acquired from SARS-CoV-2 infection was high, although it waned over time. Among unvaccinated children, the estimated effectiveness of omicron infection against reinfection with omicron was 90.7% at 2 months and 62.9% at 4 months (

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