Discovery of a novel therapeutic target for pancreatic cancer

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A novel amino acid transporter-based therapeutic target for pancreatic ductal adenocarcinoma (PDAC).

United Kingdom News, United Kingdom Headlines

By Dr. Priyom Bose, Ph.D.Oct 10 2023Reviewed by Lily Ramsey, LLM A recent Scientific Reports study identified a novel amino acid transporter-based therapeutic target for pancreatic ductal adenocarcinoma (PDAC).

Although essential amino acids are not synthesized de novo and must be obtained from external sources, non-essential amino acids can be endogenously generated through precursors. A limited number of studies have focussed on the association between SLC38A5 and cancer manifestation. The current study sought to address the research gap and assess the role of SLC38A5 in PDAC proliferation and growth.

Study findings The current study demonstrated the critical role of SLC38A5 in PDAC growth and proliferation. Experimental observations revealed that SLC38A5 plays an important part in inducing a sub-population of α-cells that triggers the development of pancreatic neuroendocrine tumors (PNETs). SLC38A5 KO also resulted in mTORC1 inhibition. Recent studies have shown that besides arginine, leucine, and methionine, mTORC1 is also activated by asparagine, histidine, glutamine, serine, threonine, alanine, and valine.

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