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Covid vaccine trials should continue | Letters

Covid vaccine trials should continue | Letters

11/27/2020 2:55:00 AM

Covid vaccine trials should continue | Letters

Letters: As millions of people will hopefully be inoculated in the next six months, this will be the ideal time for clinical trials to compare the vaccines head to head, writes Dr Andrew Hill. Plus letters from Dr Niamh Martin and Roy Grimwood

Roy Grimwood‘At this stage, we need to continue running large independent trials to further our understanding of the Covid-19 vaccines.’Photograph: Dado Ruvić/Reuters‘At this stage, we need to continue running large independent trials to further our understanding of the Covid-19 vaccines.’

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Photograph: Dado Ruvić/ReutersThu 26 Nov 2020 17.49 GMTLast modified on Thu 26 Nov 2020 18.18 GMTWVaccine results bring us a step closer to ending Covid, says Oxford scientist, 23 November). However, there are many unanswered questions. Which vaccine will protect people from Covid-19 infection for the longest time? Is one vaccine more protective for frontline healthcare workers, who could be exposed to high levels of virus? Are there any differences in safety? So far, each vaccine has been compared with a placebo in separate trials. The trials differ in designs and populations enrolled, so it is hard to compare the effectiveness and safety of these vaccines reliably.

In the next six months, millions of people in the UK will be vaccinated with vaccines from Moderna, Pfizer/BioNTech or Oxford/AstraZeneca. This is an ideal opportunity to conduct new randomised clinical trials, comparing these vaccines head to head. The NHS has discovered the survival benefits of dexamethasone in the Recovery trial. The World

HealthOrganization has shown remdesivir to be of no benefit in its Solidarity trial. At this stage, we need to continue running large independent trials to further our understanding of the vaccines. Otherwise, if there are unexpected breakthrough infections on one vaccine or new safety issues, the results could be very hard to interpret.

Dr Andrew HillDepartment of pharmacology, University of Liverpool• As a clinical academic, I was delighted to read about the scientist Prof Sarah Gilbert’s achievements in leading the charge to develop the Oxford/AstraZeneca vaccine (How a handful of scientists developed Oxford vaccine at breakneck speed

, 23 November). However, I was disheartened that you felt the need to mention that Prof Gilbert’s husband had given up work to provide childcare for their triplets. No reference was made in the next paragraph to her male colleague’s childcare arrangements.

Read more: The Guardian »

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That's the sweetest ever way to rephrase 'VaccinesforCovid19 are not fully tested' Looking for how you'll sing 'covid19vaccines aren't free' Just imagine if all the worlds bigpharma were forced by law to look for a CovidVaccine straight away at first cases, or the millionth case? We would not have been living in this mess we are right now. factsmatter

Sounds reasonable. If I take one vaccine can I take another if it proves to be better? Might as well put it on the back burner. Not like we’re having a public health emergency... 🤷 Controversial take Indefinitely thanks for this news