Covid: Trigger of rare blood clots with AstraZeneca jab found by scientists

Trigger of rare blood clots with AstraZeneca jab found by scientists

12/2/2021 9:43:00 AM

Trigger of rare blood clots with AstraZeneca jab found by scientists

Researchers in Cardiff and the US work out how the Covid jab may be linked to the extremely rare clots.

reveals the outer surface of the adenovirus attracts the platelet factor four protein to it like a magnet.Prof Alan Parker, one of the researchers at Cardiff University, told BBC News: "The adenovirus has an extremely negative surface, and platelet factor four is extremely positive and the two things fit together quite well."

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He added: "We've been able to prove the link between the key smoking guns of adenoviruses and platelet factor four."What we have is the trigger, but there's a lot of steps that have to happen next."Image source,ASUImage caption,

Incredibly detailed picture of the adenovirus, which is less than 100 nanometres across, that delivers the Oxford-AstraZeneca vaccine.The researchers think the next stage is "misplaced immunity", but this needs to be confirmed in further research.

It is thought the body starts to attack platelet factor four after confusing it for part of the foreign adenovirus to which it is stuck. So antibodies are released into the blood, which clump together with platelet factor four and trigger the formation of dangerous blood clots.

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However, this requires a series of unlucky events, which could explain why the clots are so rare.These clots, known as vaccine-induced immune thrombotic thrombocytopenia, have been linked to73 deaths out of nearly 50 million dosesof AstraZeneca given in the UK.

"You could never have predicted it would have happened and the chances are vanishingly small, so we need to remember the bigger picture of the number of lives this vaccine has saved," said Prof Parker.AstraZeneca said the vaccine is thought to have saved more than a million lives around the world and prevented 50 million cases of Covid.

The University of Oxford declined to comment on the research.Dr Will Lester, a consultant haematologist at University Hospitals Birmingham NHS Trust, praised the "very detailed" research saying it helps explain the "most likely initial step" in clotting.

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He added: "Many questions still remain unanswered, including whether some people may be more susceptible than others and why the thrombosis (clotting) is most commonly in the veins of the brain and liver, but this may come with time and further research."

The Cardiff team hope their findings can be used to improve adenovirus-based vaccines in the future to reduce the risk of these rare events.

Read more: BBC News (UK) »

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Why was then people forced to get it . Any one here Disgusting headline with no mention that COVID causes more blood clots. 0.0008% chance of getting a blood clot with vaccine. Now do a story about paracetamol and ibuprofen and how they have a higher chance of getting a blood clot. Thank God Look at that, antivax nutters: the evil pharma corporation takes action to protect people using their vaccine. What's your excuse now?

Me looking at this comment section: Nothing new there. These are rare adverse effects and the benefits of the vaccine far outweigh the very low probability of these effects. 🤔 can it be 'extremely rare' if it made them go have a look? Have they found what triggers the heart imflimation and heart attacks with the Pfizer and Moderna vaccines? And why is the AZ not being offered as a booster

So many 'rare' reactions