Certain gut microbes may be linked to skeletal health

Reviewed by Danielle Ellis, B.Sc.Sep 22 2023 If confirmed by additional research, the findings could provide the opportunity to alter gut microbiomes to achieve better bone health, as scientists learn more about "osteomicrobiology," a new term recently used to characterize this relationship.

Due to the lack of large-scale human studies of the gut microbiome and skeletal health, researchers led by Paul C. Okoro, Data Scientist II at Hebrew SeniorLife and Hinda and Arthur Marcus Institute for Aging Research, and principal investigator Douglas P. Kiel, M.D., M.P.H.

This is significant because low bone density increases the risk of developing osteoporosis, affecting more than 10 million Americans over the age of 50, and can increase the risk of fractures. Entitled "A Two-Cohort Study on the Association between the Gut Microbiota and Bone Density, Microarchitecture, and Strength," the study found that bacteria called Akkermansia, which has been associated with obesity, and Clostridiales bacterium DTU089, had negative associations with bone health for older adults.

We found patterns in which greater abundance of microbiota were associated with worse measures of bone density and microarchitecture. In fact, some bacteria were associated with differences in the bone cross sectional area, suggesting the possibility that certain microbes could influence how the bone changes size with aging. It is premature to know if the bacterial organisms themselves may have effects on skeletal health.

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Study finds connection between gut microbiome and bone densityThere is growing evidence that a relative abundance of certain gut microbes may be related to skeletal health, according to a new study published in Frontiers in Endocrinology. If confirmed by additional research, the findings could provide the opportunity to alter gut microbiomes to achieve better bone health, as scientists learn more about 'osteomicrobiology,' a new term recently used to characterize this relationship.
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