Bills & Bengals earn wildcard weekend wins

NFL play-offs: Buffalo Bills and Cincinnati Bengals win on wildcard weekend

1/16/2022 10:39:00 AM

NFL play-offs: Buffalo Bills and Cincinnati Bengals win on wildcard weekend

Buffalo Bills trounce New England Patriots 47-17 and Cincinnati Bengals hold on to beat Las Vegas Raiders on the opening night of wildcard weekend.

and retained the AFC East title this season but the manner of Saturday's win has sent a message to the rest of the NFL.The temperature at kick-off in Buffalo was -16C but fourth-year quarterback Josh Allen was on fire, making five touchdown passes as the Bills got into the end zone on each of their first seven possessions.

Allen, 25, found Dawson Knox for two touchdowns, either side of a vital Micah Hyde interception that denied the Pats an almost certain touchdown, before Devin Singletary ran in two more as the Bills led 27-3 at half-time.Mac Jones became the first rookie quarterback to feature in the play-offs for the Patriots, in their first post-season game without Tom Brady since 1998.

Read more: BBC News (UK) »

A comprehensive review about immune responses and exhaustion during coronavirus disease (COVID-19) - Cell Communication and Signaling

Coronavirus disease (COVID-19) is a viral infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. The infection was reported in Wuhan, China, in late December 2019 and has become a major global concern due to severe respiratory infections and high transmission rates. Evidence suggests that the strong interaction between SARS-CoV-2 and patients' immune systems leads to various clinical symptoms of COVID-19. Although the adaptive immune responses are essential for eliminating SARS-CoV-2, the innate immune system may, in some cases, cause the infection to progress. The cytotoxic CD8+ T cells in adaptive immune responses demonstrated functional exhaustion through upregulation of exhaustion markers. In this regard, humoral immune responses play an essential role in combat SARS-CoV-2 because SARS-CoV-2 restricts antigen presentation through downregulation of MHC class I and II molecules that lead to the inhibition of T cell-mediated immune response responses. This review summarizes the exact pathogenesis of SARS-CoV-2 and the alteration of the immune response during SARS-CoV-2 infection. In addition, we’ve explained the exhaustion of the immune system during SARS-CoV-2 and the potential immunomodulation approach to overcome this phenomenon. Video Abstract Read more >>

Bills Blow Doors Off Patriots to End Season in Wild-Card RoundFrom 2001 through 2019, the Buffalo Bills lost 34 of their 38 games against the New England Patriots. Something notable happened following the 2019 season — namely, Tom Brady’s departure for the Tampa Bay Buccaneers — which has led to the Bills winning three of four regular season meetings with the Patriots. What transpired on Saturday night at Highmark Stadium… Embarrassing !

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