Weight loss tied to a dramatic drop in cancer risk, new study shows

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NEW YORK — A large new study found that people who lost significant amounts of weight through bariatric surgery gained a striking benefit: Their likelihood of developing cancer fell sharply.

The study, published Friday in JAMA, followed more than 30,000 adults with obesity for about a decade. It found that those who underwent weight loss surgery had a 32 per cent lower risk of developing cancer and a 48 per cent lower risk of dying from the disease, compared with a similar group of people who did not have the surgery. On average, the people who had weight loss surgery lost about 55 pounds more than those who did not over the course of the study.

One expert who was not involved in the study, Dr Ania Jastreboff, said that it demonstrates that treating obesity and achieving “clinically meaningful” weight reductions can improve health outcomes for patients. “That’s a really important finding,” said Dr Jastreboff, an associate professor at the Yale School of Medicine and the director of weight management and obesity prevention at the Yale Stress Center.

According to the CDC, people with obesity tend to have higher levels of hormones such as insulin and insulin like growth factor-1, or IGF-1, which can stimulate the development of colon, kidney, prostate and endometrial cancers. According to the CDC, someone with a BMI between 25 and 30 is considered overweight and someone with a BMI above 30 is classified as obese. A large nationwide study published last year found that about 42 per cent of adults in the United States were obese and roughly 9 per cent had severe obesity.

 

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