A sign requiring masks is seen outside of a closed-down business during the ongoing coronavirus disease pandemic in Washington, US, on Dec 27, 2021.
The study, which is undergoing peer review at Nature Portfolio and was posted on Research Square on May 2, was adjusted for confounders including demographics, vaccination status, and the Charlson comorbidity index that predicts the risk of death within a year of hospitalization for patients with specific comorbid conditions.
The studies that assumed that the Omicron variant was less severe were conducted in various places including South Africa, Scotland, England, and Canada said the scientists from Massachusetts General Hospital, Minerva University and Harvard Medical School. They said their study could have several limitations, including the possibility that it underestimated the number of vaccinated patients in more recent Covid waves, and the total number of infections because it excluded patients who performed at-home rapid tests.
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