Obesity may weaken vaccine protection; unvaccinated Omicron patients face risk from variants

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The following is a summary of some recent studies on Covid-19. They include research that warrants further study to corroborate the findings and that has yet to be certified by peer review. Severe obesity may weaken the effectiveness of Covid-19 vaccines in those who have never been infected with the coronavirus, according to a small Turkish study. Among those in...

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Syringes used to administer doses of the Pfizer-BioNTech vaccine against the coronavirus disease are pictured in a sharps container at a booster clinic for 12 to 17-year-olds in Lansdale, Pennsylvania, US, on Jan 9, 2022.The following is a summary of some recent studies on Covid-19. They include research that warrants further study to corroborate the findings and that has yet to be certified by peer review.

For the study, researchers had compared immune responses to vaccines in 124 volunteers with severe obesity - defined as aof 40 or higher - and 166 normal-weight individuals . Overall, 130 participants had received two doses of the Pfizer/BioNTech mRNA vaccine and 160 had received two doses of Sinovac's inactivated-virus vaccine.

At an average of 23 days after Omicron symptoms started, unvaccinated patients had 2.2-fold lower neutralization of the first version of the Omicron variant compared to vaccinated people, 4.8-fold lower neutralization of the second Omicron sublineage, 12-fold lower Delta neutralization, 9.6-fold lower Beta variant neutralisation, and 17.9-fold lower neutralization of the original SARS-CoV-2 strain.

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