New data finds AstraZeneca booster generates higher antibodies against Omicron

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FRANKFURT — AstraZeneca said on Thursday (Jan 13) that preliminary data from a trial showed that its Covid-19 shot, Vaxzevria, generated an increase in antibodies against the Omicron and other variants when given as a third booster dose.

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The increased response, also against the Delta variant, was seen in a blood analysis of people who were previously vaccinated with either Vaxzevria or an mRNA vaccine, the drugmaker said, adding that it would submit this data to regulators worldwide given the urgent need for boosters.

The brief statement on Thursday, which did not include specific data, was the first by AstraZeneca on the protective potential of Vaxzevria as a booster shot following a two shot-course of either an mRNA based vaccine or Vaxzevria. Vaccines based on mRNA technology are made by BioNTech-Pfizer and Moderna.

The data on Vaxzevria's potential as a booster came from a comparative analysis in a trial testing a redesigned vaccine which uses the vector technology behind Vaxzevria but targeting the now-superseded Beta variant. AstraZeneca is trying to show the Beta-specific vaccine has potential also against other variants and more trial data is expected during the first half of the year.

A major British trial in December found that AstraZeneca's shot increased antibodies when given as a booster after initial vaccination with its own shot or Pfizer's, but that was before the explosive spread of the Omicron variant.

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