Moderna submits application to US regulator for Covid booster shot

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The first two Moderna doses were 100 micrograms, while the booster was half that at 50 micrograms.

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The third shot of the vaccine, known as mRNA-1273, was given to 344 participants in a study six months after their second dose.An analysis showed the booster increased neutralizing antibody levels against variants of concern, including Delta by more than 42.3-fold, Gamma by 43.6-fold, and Beta by 32-fold, with similar gains seen across age groups including over-65s.

While Moderna is submitting data for a repetition of its first vaccine, which was developed against the original strain first identified in Wuhan, China, the company has previously tested a variant-specific booster against Beta, which was first identified in South Africa but has faded considerably in recent months.

That decision has left many health experts baffled, because although there is evidence that vaccine efficacy is waning against infection, it has remained largely stable against hospitalization and deaths -- the purpose for which the shots were conceived.

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