Moderna says COVID-19 vaccine protection wanes, makes case for booster

Moderna says COVID-19 vaccine protection wanes, makes case for booster

16/9/2021 2:53:00 AM

Moderna says COVID-19 vaccine protection wanes, makes case for booster

CHICAGO: New data from Moderna\u0027s large COVID-19 vaccine trial shows that the protection it offers wanes over time, supporting the case for booster doses, the company said in a news release on Wednesday (Sep 15). \u0022This is only one estimate, but we do believe this means as you look toward the fall and winter

, released earlier on Wednesday, suggest that a key issue the agency will consider is whether vaccine protection is waning.Hoge said data from its booster studies shows the vaccine could increase neutralising antibodies to levels even higher than were seen after the second dose.

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"We believe this will reduce COVID-19 cases," he said."We also believe that a third dose of mRNA-1273 has a chance of significantly extending immunity throughout much of next year as we attempt to end the pandemic."In its analysis, Moderna compared the vaccine's performance in more than 14,000 volunteers vaccinated between July and October of 2020 with around 11,000 volunteers originally in the placebo group who were offered the shot between December 2020 and March 2021 following its US emergency-use authorisation.

In July and August this year, researchers identified 88 COVID-19 cases among those who got the two shots in the recent period, compared with 162 cases among those vaccinated earlier. Overall, only 19 cases were considered severe, a key benchmark in assessing waning protection.

Moderna said there was a trend toward a lower rate of severe cases among the more recently vaccinated, although the finding was not statistically significant.Related:Singapore studying possibility of non-mRNA vaccines for COVID-19 booster shots: Janil Puthucheary

Data from a separate study presented on Wednesday conducted with Kaiser Permanente Southern California health system, meanwhile, shows that Moderna's vaccine continued to perform well against the Delta variant.Researchers compared data on more than 352,000 people who got two doses of the Moderna vaccine with the same number of unvaccinated individuals and found the Moderna vaccine was 87 per cent effective at preventing a COVID-19 diagnosis, and 96 per cent effective at preventing hospitalisation.

Hoge said the vaccine's initial performance is strong, but argued that protection should not be allowed to wane. Read more: CNA »

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