Sub-Saharan Africa, İnfectious Disease, Drug-Resistant, Institut Pasteur, Artemisinin, World Health Organization, Africa, Columbia University

Sub-Saharan Africa, İnfectious Disease

Malaria: drug-resistant parasites discovered in sub-Saharan Africa

Researchers are sounding the alarm about the presence of malaria-causing parasites that are resistant to artemisinin, the molecule used to treat this infectious disease.

6/8/2020 1:00:00 PM

Researchers are sounding the alarm about the presence of malaria-causing parasites that are resistant to artemisinin, the molecule used to treat this infectious disease .

A report published in the journal Nature Medecine is sounding the alarm about the presence of malaria-causing parasites that are resistant to artemisinin, the molecule used to treat this infectious disease . The drug ACT has been the anti-malarial treatment recommended by the World Health Organization

The drug ACT has been the anti-malarial treatment recommended by the World Health Organization for the past 15 years. It is made of a fast-acting derivative of artemisinin, an essential molecule for treating the disease. A mutation of the K13 gene in the parasites of the Plasmodium genus can cause the development of resistance to this molecule. The discovery of a significant presence of drug-resistant parasites in the sub-Saharan region is very bad news, as 90% of malaria cases are concentrated there.

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Closely monitored developmentsThis mutation, rare in Africa, has recently been detected in Guyana and Papua New Guinea. The organizations which carry out molecular monitoring of drug resistance in Africa, including the researchers at France's Pasteur Institute, have measured the emergence of parasites carrying the mutation that are thus resistant in vitro to treatments derived from artemisinin.

Other cases of resistance in the pastDuring the 1980s, resistance to the treatment then used against malaria, chloroquine, became widespread. This is thought to have led to the deaths of several million people, especially small children. A simulation of the same scenario occurring with artemisinin predicts a disastrous 78 million cases and 116,000 additional deaths.

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