Malaria: drug-resistant parasites discovered in sub-Saharan Africa

A report published in the journal Nature Medecine is sounding the alarm about the presence of malaria-causing parasites that are resistant to artemisinin, the molecule used to treat this infectious disease. Their presence has been detected in several countries in sub-Saharan Africa through research conducted by the Institut Pasteur, along with the National Malaria Control Program in Rwanda , the WHO, Cochin Hospital and Columbia University in New York, USA.

The drug ACT has been the anti-malarial treatment recommended by the World Health Organization for the past 15 years. It is made of a fast-acting derivative of artemisinin, an essential molecule for treating the disease. A mutation of the K13 gene in the parasites of the Plasmodium genus can cause the development of resistance to this molecule.

Malaria is transmitted by parasites of the genus Plasmodium and is present in 89 countries worldwide. It represents a significant public health threat, as it represents 3.2 billion potentially exposed to this infection. There is still no vaccine against the disease.

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