CHICAGO: Johnson & Johnson said Tuesday a second shot of its COVID-19 vaccine given about two months after the first increased its effectiveness to 94 per cent in the United States against moderate to severe forms of the disease.The data will help J&J make its case to US regulators for a booster shot even as the company stresses the durability of its single-shot vaccine as a tool to ease the global pandemic.
J&J said a booster given two months after the first dose increased antibody levels four to six-fold. When given six months after the first dose, antibody levels shot up twelve-fold, data released last month showed, suggesting a large improvement in protection with the longer interval between doses. On Friday, an FDA advisory committee voted to recommend emergency authorisation of additional Pfizer shots for Americans 65 and older and those at high risk of severe illness, but voted to recommend against broader approval, saying they want to see more data.Commentary: Why the US FDA is taking a wait-and-see attitude on booster shots for US public
While the study found that two doses of the J&J vaccine was 94 per cent effective in the United States at preventing moderate to severe disease, there was only one case in the vaccine group and 14 in the placebo group, resulting in a wide confidence interval and raising questions about the certainty of the result.
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