In a first, US man receives a heart from a genetically altered pig

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CHICAGO - A 57-year-old man with life-threatening heart disease has received a heart from a genetically modified pig, a groundbreaking procedure that offers hope to hundreds of thousands of patients

with failing organs.

Last year, some 41,354 Americans received a transplanted organ, more than half of them receiving kidneys, according to the United Network for Organ Sharing, a non-profit that coordinates the nation's organ procurement efforts.Some 3,817 Americans received human donor hearts last year as replacements, more than ever before, but the potential demand is still higher.

"This is a watershed event," said Dr David Klassen, chief medical officer of the United Network for Organ Sharing and a transplant physician."Doors are starting to open that will lead, I believe, to major changes in how we treat organ failure." The new heart is functioning and already doing most of the work, and his doctors said he could be taken off the machine Tuesday.

Xenotransplantation, the process of grafting or transplanting organs or tissues from animals to humans, has a long history. Efforts to use the blood and skin of animals go back hundreds of years. Pig heart valves are routinely transplanted into humans, and some patients with diabetes have received porcine pancreas cells. Pig skin has also been used as a temporary graft for burn patients.

The heart transplanted into Mr Bennett came from a genetically altered pig provided by Revivicor, a regenerative medicine company based in Blacksburg, Virginia.

 

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