The US Food and Drug Administration on Thursday recommended COVID-19 vaccine manufacturers change the design of their booster shots beginning this fall to include components tailored to combat the currently dominant Omicron BA.4 and BA.5 subvariants of the coronavirus.
"In a sense, we are chasing the virus, just as we do with influenza, and how close we can get to the variants that are prominent at the time, we'll have to wait and see," said Dr. William Schaffner, an infectious disease expert at Vanderbilt University Medical Center, adding that the redesigned vaccines could provide better protection than the current ones.
The decision follows a recommendation by the agency's outside advisers to change the design of the shots this fall in order to combat more prevalent versions of the coronavirus. Scientists have suggested that introducing redesigned boosters could spur broader range of immune responses that might also protect against future variants, even if they are not the ones currently circulating.
Although they have said those vaccines generated a good immune response against BA.1 and the more recently circulating variants, they did see a lower response against BA.4 and BA.5.
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