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However, some changes may affect how easily they spread, their severity or the performance of vaccines against them. That is about double the number of Delta, and makes this variant substantially different from the original coronavirus that current COVID-19 vaccines were designed to counteract. UK Health Security Agency Chief Medical Advisor Dr Susan Hopkins told BBC radio some mutations had not been seen before, so it was not known how they would interact with the other ones, making it the most complex variant seen so far.
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