A chain of events possibly triggered by unrecognized infection with the Sars-CoV-2 coronavirus could be causing the mysterious cases of severe hepatitis reported in hundreds of young children around the world, researchers suggest.
It is possible that the affected children, many of whom are too young to be vaccinated, may have had mild or asymptomatic Covid infections that went unnoticed, a separate team of researchers suggest inIf that were true, they theorize, then lingering particles of the coronavirus in the gastrointestinal tract in these children could be priming the immune system to over-react to adenovirus-41F with high amounts of inflammatory proteins that ultimately damage the liver.
In the study, 400 patients were randomly assigned to usual care or to standard care plus intermittently lying on their stomachs, a position known to improve the course of illness in sedated patients on mechanical ventilators.
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