Commentary: Why Omicron is a much milder mutation

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Omicron has caused less severe disease due to the different way it interacts with our bodies, says a professor.

Of course, if daily Omicron infections rise to a very high number, as they have, then hospitalisations will also rise. In the final few days of 2021, hospital admissions of COVID-positive people increased quite substantially, but still didn’t surpass levels seen during previous waves.

For protection against an initial infection, located in the nose and throat, antibodies against a key part of the coronavirus’s outer structure – its spike protein – appear to play the greatest role. Residents wearing face masks to protect from the coronavirus receive a coronavirus test during a mass testing inside a tent in north China's Tianjin municipality, Sunday, Jan. 9, 2022.

This could be a powerful explanation as to why Omicron’s virulence appears lower. In the UK, for example, it’s estimated that close to 95 per cent of adults have some form of immunity to the virus through vaccination or infection.But might Omicron also be intrinsically less virulent than previous variants, even in those with no prior immunity? This is more difficult to be certain of, though there are some signs that suggest it might be.

 

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