A Chilean tree holds hope for new vaccines - if supplies last

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Two saponin molecules, made from the bark of branches pruned from older quillay trees, are being used for a COVID-19 vaccine developed by drugmaker Novavax. The chemicals are used to make adjuvant, a substance that boosts the immune system.

Aislinn Laing and Allison MartellCASABLANCA, Chile -Down a dusty farm track in Chilean wine country, behind a wooden gate wrapped in chains, forestry experts are nursing a plantation of saplings whose bark holds the promise of potent vaccines.

With no reliable data on how many healthy quillay trees are left in Chile, experts and industry officials are divided on how quickly the supply of older trees will be depleted by rising demand. But nearly everyone agrees that industries relying on quillay extracts will at some point need to switch to plantation-grown trees or a lab-grown alternative.

“I am working as though this needs to be done yesterday,” said San Martin, who is also sponsoring a project in which drones would count quillay trees in remote and hard-to-access forests, to determine how many are left. The company’s manager in Chile, Andres Gonzalez, told Reuters it is set to produce enough quillay extract from older trees to make up to 4.4 billion vaccine doses in 2022. With new supplies from privately owned native forests, they have enough raw material to meet demand for the rest of this year and part of next, he said.

Among major pharmaceutical companies, only GlaxoSmithKline PLC and Novavax have bet heavily on QS-21, a relatively new pharmaceutical ingredient.

 

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