US and Gates Foundation plan $200m for sickle cell, HIV cures

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WASHINGTON — The US government and the Bill and Melinda Gates Foundation pledged Wednesday to jointly invest $200 million over the next 4 years to achieve affordable gene therapy-based cures for sickl

e cell disease and HIV.

The NIH and Gates Foundation aim to achieve clinical trials in the United States and countries in sub-Saharan Africa within the next seven to 10 years. When it comes to HIV, antiretroviral therapy are now able to reduce patients' viral load to the point that they are undetectable and cannot be further transmitted.

The goal for SCD is to achieve a gene-based intervention that either corrects the gene mutation responsible or promotes fetal hemoglobin gene expression to achieve normal hemoglobin function.

 

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