Pre-orders of COVID-19 vaccines top 5 billion

Although none of the coronavirus vaccines under development has proved its efficacy yet in clinical trials, at least 5.7 billion doses have been pre-ordered around the world.

In a surprise announcement, Russian President Vladimir Putin claimed Tuesday that a vaccine dubbed "Sputnik V" -- after the Soviet satellite -- conferred "sustainable immunity" against the novel coronavirus. Hundreds of millions of dollars have been directed to vaccine developers including nearly $500 million to Johnson & Johnson at the end of March.

The companies involved are: Johnson & Johnson, Moderna, Oxford/AztraZeneca, Novavax, Pfizer/BioNTech, Sanofi/GSK, Merck Sharp and Dohme.Two vaccine developers -- Oxford/AztraZeneca and Sanofi/GSK -- have signed or are in advanced negotiations with the European Commission to provide a combined 700 million vaccine doses.Britain, because of Brexit, is negotiating a separate pre-order of 250 million doses from four developers.

Brazil chose a similar model, ordering 100 million doses from AstraZeneca, and partnering with China's Sinovac to produce 120 millions of "CoronaVac," which is already undergoing testing with Brazilians.Clinical tests of two Chinese vaccine candidates -- Sinovac and Sinopharm -- are well underway but only a few international partnerships have been announced, the one with Brazil and a possible one with Indonesia.

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