Pig-to-human transplants come a step closer with new test

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SCIENTISTS temporarily attached a pig’s kidney to a human body and watched it begin to work, a small step in the decades-long quest to one day use...

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SCIENTISTS temporarily attached a pig’s kidney to a human body and watched it begin to work, a small step in the decades-long quest to one day use animal organs for life-saving transplants.

“It had absolutely normal function,” said Dr. Robert Montgomery, who led the surgical team last month at NYU Langone Health. “It didn’t have this immediate rejection that we have worried about.” With no lasting success and much public uproar, scientists turned from primates to pigs, tinkering with their genes to bridge the species gap.

In the NYU case, researchers kept a deceased woman's body going on a ventilator after her family agreed to the experiment. The woman had wished to donate her organs, but they weren’t suitable for traditional donation.Montgomery himself received a transplant three years ago, a human heart from a donor with hepatitis C because he was willing to take any organ. “I was one of those people lying in an ICU waiting and not knowing whether an organ was going to come in time,” he said.

The pigs lack a gene that produces alpha-gal, the sugar that provokes an immediate attack from the human immune system.

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