High-fat diet cuts ‘brake’ used to control appetite | The Guardian Nigeria News - Nigeria and World News

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“Obesity does not just happen overnight.” Nigeria

The result helps untangle the complex relationship between food and appetite, one that can become muddled when people overeat.

Called the lateral hypothalamus, this brain structure contains a large number of diverse cells. Stuber and his colleagues looked at gene behavior in single cells there, and found that one group, called glutamatergic nerve cells, showed particularly big changes in which genes were active when the team compared lean mice with obese mice.

“Obesity does not just happen overnight,” says Stuber, who conducted some of the work while at the University of North Carolina at Chapel Hill. To study that gradual transition, the researchers began feeding mice high-fat mouse chow, while periodically using a sophisticated microscope to look at the glutamatergic cells’ ability to fire off signals.

The results imply that “these cells’ decreased activity is removing the brake on feeding and obesity,” says neuroscientist Stephanie Borgland of the University of Calgary in Canada, who wrote a related commentary in the same issue of Science.The researchers do not know whether these cells would regain their normal behavior if the mice stopped eating high-fat food and shed weight.

 

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Paradigm shift from the consumption of local/ traditional diets to ' junks' that are highly laden with free sugars is an important driver of obesity surge in our society

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