When implanted into mouse embryos, stem cells from rats grew into forebrains and structures that handle smells.
What does it feel like to be a rat? We will never know, but some very unusual mice may now have an inkling.
The success of these rat-mouse hybrids depended on timing: The rat and mouse cells had to grow into brains together from a very young stage. Stem cells from rats that had the potential to mature into several different cell types were injected into mouse embryos. From there, these rat cells developed alongside mice cells in the growing brain, though researchers couldn’t control exactly where the rat cells ended up.for these rat cells to develop in the young mouse brains.
Structures made of rat nerve fibers that help animals sense particular odor molecules formed in the brains of mice, alongside a mix of structures made of rat and mouse nerve fibers or just mouse . This hybrid mouse-rat smell system can help scientists understand how flexible brains can be.). The team put donor rat stem cells into embryos of mice engineered to have damaged smell systems.
In both studies, a close look at the rat donor cells showed that they adopted many of the traits of surrounding mouse cells. Rat cell size, growth timing and cellular targets looked less like rat cells and more like mouse cells, the researchers found. That suggests the environment the cell grows up in can strongly influence the cell, regardless of its species identity.
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