Blockage of arterial blood vessels caused by atherosclerosis is largely responsible for heart attacks and strokes, which are the most common causes of death worldwide. The complex mechanisms that lead to pathological changes in the arteries are not yet fully understood.
An international research team has now made important progress in understanding this disease and identified potential new approaches for early detection and therapy.
In the search for the solution to this puzzle, Christoph Binder and Florentina Porsch from MedUni Vienna's Department of Laboratory Medicine, in collaboration with Clément Cochain, Alma Zernecke and Marie Piollet from the University Hospital of Würzburg, took a closer look at the protein TREM2. TREM2 controls the activity of macrophages and therefore has a potential influence on the development of atherosclerosis.
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