Two independent research teams have achieved successful regeneration of mouse brain circuits by cultivating neurons from rat stem cells.
The findings provide valuable insights into the formation of brain tissue and offer new prospects for reinstating lost brain function. Both studies, published in the journal, provide valuable insights into the formation of brain tissue and offer new prospects for reinstating lost brain function resulting from disease and aging.
Baldwin’s team restored the neural circuits responsible for the sense of smell in mice, known as olfactory neural circuits, along with their functionality, using stem cells sourced from rats. Wu’s team devised a CRISPR-based platform capable of efficiently identifying specific genes that drive the development of particular tissues. They tested the platform by deactivating a gene crucial for forebrain development in mice and subsequently restoring the tissue using rat stem cells.The researchers discovered that blastocyst complementation led to different outcomes in restoring mouse olfactory neural circuits depending on the model used.
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