Findings from two phase 3 trials demonstrate that the aztreonam-avibactam combination safely treats gram-negative bacterial infections.
-avibactam), recommended for treating complicated intra-abdominal and urinary tract infections, hospital-acquired pneumonia, and infections stemming from specific types of bacteria where therapeutic choices are restricted.that in 2020, more than 670,000 drug-resistant bacterial infections occurred in the European Union/European Economic Area alone, resulting in approximately 33,000 deaths.
The REVISIT trial enrolled people from regions where there is suspicion of multidrug-resistant pathogens and endemic or emerging carbapenem resistance. It recruited 422 hospitalized adults with complicated intra-abdominal infections , hospital-acquired pneumonia , and ventilator-associated pneumonia . Patients received Emblaveo with or without metronidazole.
In patients with cIAI, the Emblaveo regimen demonstrated a cure rate of 76.4%, compared with 74.0% for those treated with meropenem with or without. For HAP and VAP, the corresponding cure rates were 45.9% and 41.7% for Emblaveo and meropenem regimens, respectively. Although Emblaveo showed superior cure rates in both cases, the treatment effect did not reach statistical significance.
Emblaveo was found to be well tolerated, with a balanced occurrence of serious adverse events between treatment and control groups. Side effects includeThe ASSEMBLE study subsequently corroborated these findings, focusing on patients hospitalized for metallo-beta-lactamase–producing gram-negative bacteria. The Emblaveo regimen achieved a cure rate of 41.7% among treated patients, whereas none of those receiving the best available therapy were cured.
Though these trials were not primarily designed to demonstrate efficacy, they contribute safety and supplementary insights into the combination. This approach aligns withAntibiotic Use Decreased, Resistance Stable in GermanyAll material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC. This website also contains material copyrighted by 3rd parties.
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