A sign is seen at an AstraZeneca site in Macclesfield, central England May 19, 2014. — Reuters pic
“Ironically, if we're really successful using public health measures to stamp out the hot spots of viral infection, it will be harder to test the vaccine,” said Francis Collins, director of the National Institutes of Health in the United States. “The solution is to move to areas where the infection is being spread widely in the community – that would be countries like Brazil and Mexico at the moment.”
A similar problem emerged when scientists were seeking to test potential new vaccines against Ebola during the vast 2014 outbreak in West Africa. Then, drugmakers were forced to drastically scale back plans for large trials because their vaccines were only test-ready late in the epidemic when case numbers were dwindling.Among the first Covid-19 vaccines to move into Phase II, or mid-stage, trials is one from the US biotech company Moderna Inc.
Adrian Hill, director of the Jenner Institute at Britain's Oxford University which has teamed up with AstraZeneca, started mid-stage trials last month which he said would aim to recruit around 10,000 people in Britain.
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