WASHINGTON, Dec 10 — An experimental HIV vaccine based on mRNA — the same technology used in two highly successful Covid-19 vaccines — has shown promise in experiments in mice and monkeys, according to a study published Thursday inThe research, which was carried out by scientists at the National Institute of Allergy and Infectious Diseases , Moderna and other institutions, demonstrated that the vaccine was safe and prompted desired antibody and cellular immune responses against an HIV-like...
“This experimental mRNA vaccine combines several features that may overcome shortcomings of other experimental HIV vaccines and thus represents a promising approach.” Muscle cells in an inoculated animal build the two proteins, producing virus-like particles that are dotted with many copies of Env on their surface.
Co-author Paolo Lusso, also of NIAID, said these more “authentic” copies of the protein more closely mimicked natural infection than past efforts.The exact regimen differed among the animals, but involved priming the immune system with a vaccine optimised towards antibody creation, followed by boosters over the course of a year.
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