The discovery is the most horrific incident of human smuggling over the US-Mexico border in recent times.
The city's Police Chief William McManus said a person who works in a nearby building heard a cry for help and came out to investigate. Mr McManus said this was the largest incident of human smuggling in the city and said three people were in custody following the incident, though their involvement is not yet clear.
Mexico's Foreign Minister Marcelo Ebrard called the incident a "tragedy in Texas" on Twitter and said consular officials would go to the hospitals where victims had been taken to help "however possible".
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