COVID-19 vaccine makers have been updating their shots to better match omicron in case global health authorities decide the change is needed.While Omicron is more likely than previous variants to cause infection even in people who've been vaccinated, it's not yet clear that a change to the vaccine recipe is needed.Studies in the US and elsewhere have made clear that adding a booster dose strengthens that protection and improves the chances of avoiding a milder infection.
The new US study is enrolling up to 1420 healthy adults, ages 18 to 55, to test the updated Omicron-based shots for use as a booster or for primary vaccinations. In one study group, about 600 volunteers who received two doses of the current Pfizer vaccine three to six months ago will receive either one or two omicron-based shots as boosters.
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