Immune reactions to severe Covid may trigger brain problems, study finds

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Research suggests immune response may be cause of delirium and brain fog in Covid patients

Severe Covid infections can cause immune reactions that damage nerve cells in the brain, causing memory problems and confusion, and potentially raising the risk of long-term health issues, research suggests.

“These neurological symptoms are very concerning for patients and their families, and the hope is that our research can help identify which treatments would be most appropriate to lessen or prevent these symptoms,” said Carmine Pariante, a professor of biological psychiatry at KCL’s Institute of Psychiatry, and senior author on the study.

The harmful effects were traced back to a cascade of events where IL-6 triggers the release of two related immune proteins, called IL-12 and IL-13. Dr Alessandra Borsini, the study’s first author, said the impact of the proteins on generating new brain cells was “profound”.Molecular Psychiatry

 

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